Doctor of Philosophy in Molecular Genetics - Cellular and Molecular Structure and Function
在多倫多大學
關於課程
Our research interests in the area of Cellular and Molecular Structure and Function range from computational protein folding to stem cell biology. Despite the breadth, there are a number of themes that can be identified, all of which are centred on understanding fundamental mechanisms. Several labs are focussed on neuronal development and neuronal tissue function, for example, work that includes the study of neuronal stem cell generation, axon guidance mechanisms and the molecular basis for neural network formation. Central to these efforts is the study of stem cells and the use of a number of different animal models. Cutting-edge techniques involving laser optics and optogenetics are leveraged to study higher-order functions such as learning, memory and locomotion. Stem cells and animal models, including the zebra fish, are also being used to study development and disease in other systems and tissues including the heart and kidney. Collectively, the advances emerging from these efforts are expected to contribute to novel approaches to treating neural and heart tissue damage, brain cancers in children and Alzheimer's disease in the elderly to name just a few.
Genome stability through successive cell divisions is central to the maintenance of normal cellular function. Not surprisingly, DNA damage and the gain or loss of chromosomes or portions of them are hallmarks of cancer. Several MoGen labs are working to understand DNA repair mechanisms and the processes that ensure proper chromosome replication and segregation. In one collaborative effort, functional genomics, microscopy and mass-spectrometry are being used to study centrosome biogenesis, an important component in the regulation of cell division. In another collaboration, cell-based approaches and x-ray crystallography are utilized to determine how DNA repair enzymes are recruited to double-strand breaks.
Genome stability through successive cell divisions is central to the maintenance of normal cellular function. Not surprisingly, DNA damage and the gain or loss of chromosomes or portions of them are hallmarks of cancer. Several MoGen labs are working to understand DNA repair mechanisms and the processes that ensure proper chromosome replication and segregation. In one collaborative effort, functional genomics, microscopy and mass-spectrometry are being used to study centrosome biogenesis, an important component in the regulation of cell division. In another collaboration, cell-based approaches and x-ray crystallography are utilized to determine how DNA repair enzymes are recruited to double-strand breaks.
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Entry requirements for 多倫多大學
Applicants to our Graduate Program must have: an A- average or higher in their M.Sc. or B.Sc. to be considered for our Ph.D. program. TOEFL: Paper-Based Test and TWE- Overall Score 580 TWE: 5, Internet-Based Test (IBT): 93, Writing/Speaking: 22. IELTS: Minimum required score: 7.0 (Academic)with at least 6.5 for each component.
English language requirements
托福(TOEFL iBT)總分: 93.0
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